{"id":2109,"date":"2022-08-25T14:09:54","date_gmt":"2022-08-25T14:09:54","guid":{"rendered":"https:\/\/science.tdmu.edu.ua\/?p=2109"},"modified":"2022-08-25T14:09:54","modified_gmt":"2022-08-25T14:09:54","slug":"why-are-men-more-prone-to-cancer-than-women","status":"publish","type":"post","link":"https:\/\/www.tdmu.edu.ua\/science\/en\/why-are-men-more-prone-to-cancer-than-women\/","title":{"rendered":"Why are Men More Prone to Cancer than Women?"},"content":{"rendered":"\n<p class=\" eplus-wrapper\">The&nbsp;<a href=\"https:\/\/www.cancer.org\/healthy\/cancer-causes\/general-info\/lifetime-probability-of-developing-or-dying-from-cancer.html\">overall risk<\/a>&nbsp;of developing cancer is about the same for men and women (40.2% and 38.5%, respectively).&nbsp; However, when excluding sex-specific cancers (like ovarian and testicular cancers), cancer risk becomes significantly higher in men than women, a detail that scientists have recognized for years.&nbsp; In fact, when considering cancers that develop in anatomic sites shared by men and women, men have more than a two-fold&nbsp;<a href=\"https:\/\/aacrjournals.org\/cebp\/article\/18\/4\/1174\/164658\/Sex-Disparities-in-Cancer-Incidence-by-Period-and\">greater risk<\/a>&nbsp;of most cancers than women.&nbsp; While research attributes some of these differences to behavioral factors, like&nbsp;<a href=\"https:\/\/tobaccocontrol.bmj.com\/content\/20\/2\/166.long\">smoking and alcohol use<\/a>, or personal characteristics, like&nbsp;<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0923753420360579\">height<\/a>&nbsp;, the increased cancer risk in men remains poorly understood.&nbsp; Additionally, there is evidence of a more active&nbsp;<a href=\"https:\/\/www.nature.com\/articles\/nri.2016.90\">immune response<\/a>&nbsp;in women compared to men, which could account for some differences in cancer incidence.&nbsp;<\/p>\n\n\n\n<p class=\" eplus-wrapper\">A new study published in&nbsp;<em><a href=\"https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/epdf\/10.1002\/cncr.34390\">Cancer<\/a><\/em>&nbsp;suggests that biological factors may be a major factor contributing to the sex disparities seen in cancer incidence.&nbsp; The authors came to this conclusion through a highly selective process of elimination.&nbsp;<\/p>\n\n\n\n<p class=\" eplus-wrapper\">The researchers conducted a prospective cohort analysis of over 170,000 males and over 120,000 females aged 50 \u2013 71.&nbsp; Participants enrolled in the&nbsp;<a href=\"https:\/\/dietandhealth.cancer.gov\/history.html\">NIH-AARP Diet and Health Study<\/a>&nbsp;between 1995 and 1996, at which time they completed a questionnaire on diet and lifestyle.&nbsp; Over the next ten years, participants also provided information on risk factors like physical activity, cancer screening, and family history.&nbsp; Investigators obtained outcome data, including cancer diagnoses and death, from cancer registries and other databases.&nbsp;<\/p>\n\n\n\n<p class=\" eplus-wrapper\">The study evaluated 21 different types of cancer.&nbsp; Based on an extensive review of relevant literature for each cancer site, the researchers considered different variables for each type of cancer.&nbsp; The investigators then used statistical analyses to estimate male-to-female&nbsp;<a href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/hazard-ratio\">hazard ratios<\/a>, a measurement of how often an event occurs in males compared to females.&nbsp;<\/p>\n\n\n\n<p class=\" eplus-wrapper\">The analysis revealed over 26,000 cancer diagnoses (17,951 in men and 8,742 in women).&nbsp; As expected, most cancers showed a higher cancer burden in men than women.&nbsp; The most considerable differences in risk appeared in cancers of the esophagus (10.8 times higher), bladder (3.5 times higher), larynx (3.5 times higher), and gastric cardia (3.3 times higher).&nbsp; Two cancer sites, the thyroid and gallbladder, revealed higher incidence in women than men.&nbsp; The risk factors evaluated explained a proportion of the measured excess male diagnoses for many cancers.&nbsp; However, the risk factors didn\u2019t account for more than half of the male excess for any cancer evaluated.&nbsp; Sex disparate risk factors had the most significant impact on lung cancer, in which 49.5% of the difference in risk was attributable to risk factors.&nbsp;<\/p>\n\n\n\n<p class=\" eplus-wrapper\">The authors demonstrate that sex-related risk factors account for some, but not all, of the male predominance of cancer that has been long acknowledged but poorly understood.&nbsp; The authors conclude that their analysis suggests biological factors could explain the remaining discrepancies in cancer incidence between the sexes. &nbsp;Understanding these potential biological mechanisms could provide valuable clues to improve diagnosis, treatment, and prevention strategies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The&nbsp;overall risk&nbsp;of developing cancer is about the same for men and women (40.2% and 38.5%, respectively).&nbsp; However, when excluding sex-specific cancers (like ovarian and testicular cancers), cancer risk becomes significantly higher in men than women, a detail that scientists have recognized for years.&nbsp; In fact, when considering cancers that develop in anatomic sites shared by [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":2111,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_gspb_post_css":"","_uag_custom_page_level_css":"","advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[28],"tags":[],"class_list":["post-2109","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news_tnmu-en"],"author_meta":{"display_name":"admin","author_link":"https:\/\/www.tdmu.edu.ua\/science\/author\/admin\/"},"featured_img":"https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg","uagb_featured_image_src":{"full":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false],"thumbnail":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4-150x150.jpg",150,150,true],"medium":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false],"medium_large":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false],"large":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false],"1536x1536":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false],"2048x2048":["https:\/\/www.tdmu.edu.ua\/science\/wp-content\/uploads\/sites\/19\/2022\/08\/unnamed-4.jpg",300,150,false]},"uagb_author_info":{"display_name":"admin","author_link":"https:\/\/www.tdmu.edu.ua\/science\/author\/admin\/"},"uagb_comment_info":0,"uagb_excerpt":"The&nbsp;overall risk&nbsp;of developing cancer is about the same for men and women (40.2% and 38.5%, respectively).&nbsp; However, when excluding sex-specific cancers (like ovarian and testicular cancers), cancer risk becomes significantly higher in men than women, a detail that scientists have recognized for years.&nbsp; In fact, when considering cancers that develop in anatomic sites shared by&hellip;","coauthors":[],"tax_additional":{"categories":{"linked":["<a href=\"https:\/\/www.tdmu.edu.ua\/science\/en\/category\/news_tnmu-en\/\" class=\"advgb-post-tax-term\">News TNMU<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">News TNMU<\/span>"]}},"comment_count":0,"relative_dates":{"created":"Posted 4 \u0440\u043e\u043a\u0438 ago","modified":"Updated 4 \u0440\u043e\u043a\u0438 ago"},"absolute_dates":{"created":"Posted on 25.08.2022","modified":"Updated on 25.08.2022"},"absolute_dates_time":{"created":"Posted on 25.08.2022 14:09","modified":"Updated on 25.08.2022 14:09"},"featured_img_caption":"","series_order":"","_links":{"self":[{"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/posts\/2109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/comments?post=2109"}],"version-history":[{"count":0,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/posts\/2109\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/media\/2111"}],"wp:attachment":[{"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/media?parent=2109"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/categories?post=2109"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.tdmu.edu.ua\/science\/wp-json\/wp\/v2\/tags?post=2109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}