Department of Pharmacology and Clinical Pharmacology
Responsible for implementation – Professor Kateryna Posokhova
There is no medicinal agent which, when used at therapeutic doses, would not lead to any side effects. The best way to prevent them is to adequately prescribe drugs and to have detailed information about their side effects. Unfortunately, the information about drugs, which is presented in the instructions for their medical use, is not always taken into account by doctors, especially in the situations when medicinal agents should be used in combination. That’s why doctors should know the main pharmacokinetic properties of the drugs, especially their interaction at the level of the
microsomal enzyme system of the liver. Doctors are usually poorly informed about the effects of medicinal agent depending on the genetic characteristics of the patient. At the same time, the spectrum of such side effects can differ over a wide range – from lack of treatment effectiveness to severe, sometimes fatal, complications. Thus, to improve the results of pharmacotherapy and to prevention effectively undesirable reactions and complications of the drugs, it is necessary to highlight the following points in the process of medicine study:
– Typical side effects of a particular group of drugs.
– Contraindications and warnings when using certain groups of drugs.
– Results of pharmacokinetic interaction of drugs: at the stages of absorption, binding to plasma proteins, biotransformation and excretion.
– Results of pharmacodynamic interaction of drugs.
– The role of genetic characteristics of the organism in the action of drugs and the occurrence of side effects.
– State policy in ensuring effective and safe pharmacotherapy. Pharmacovigilance. Role of the State Expert Center of the Health Ministry of Ukraine.